WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene_protein-coding, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=12; E=1.06; R=11.34; rawP=7.10e-10; adjP=2.84e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000161547 NA SRSF2 serine/arginine-rich splicing factor 2 6427 ENSG00000161547
2  ENSG00000134748 NA PRPF38A PRP38 pre-mRNA processing factor 38 (yeast) domain containing A 84950 ENSG00000134748
3  ENSG00000147274 NA RBMX RNA binding motif protein, X-linked 27316 ENSG00000147274
4  ENSG00000164548 NA TRA2A transformer 2 alpha homolog (Drosophila) 29896 ENSG00000164548
5  ENSG00000124193 NA SRSF6 serine/arginine-rich splicing factor 6 6431 ENSG00000124193
6  ENSG00000160201 NA U2AF1 U2 small nuclear RNA auxiliary factor 1 7307 ENSG00000160201
7  ENSG00000115875 NA SRSF7 serine/arginine-rich splicing factor 7 6432 ENSG00000115875
8  ENSG00000136527 NA TRA2B transformer 2 beta homolog (Drosophila) 6434 ENSG00000136527
9  ENSG00000108654 NA DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 1655 ENSG00000108654
10  ENSG00000112081 NA SRSF3 serine/arginine-rich splicing factor 3 6428 ENSG00000112081
11  ENSG00000170144 NA HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 220988 ENSG00000170144
12  ENSG00000136450 NA SRSF1 serine/arginine-rich splicing factor 1 6426 ENSG00000136450


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=14; E=2.21; R=6.34; rawP=5.05e-08; adjP=1.01e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128342 NA LIF leukemia inhibitory factor 3976 ENSG00000128342
2  ENSG00000108342 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
3  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
4  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
5  ENSG00000108700 NA CCL8 chemokine (C-C motif) ligand 8 6355 ENSG00000108700
6  ENSG00000163734 NA CXCL3 chemokine (C-X-C motif) ligand 3 2921 ENSG00000163734
7  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
8  ENSG00000124875 NA CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 6372 ENSG00000124875
9  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
10  ENSG00000081041 NA CXCL2 chemokine (C-X-C motif) ligand 2 2920 ENSG00000081041
11  ENSG00000173530 NA TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 8793 ENSG00000173530
12  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
13  ENSG00000026103 NA FAS Fas (TNF receptor superfamily, member 6) 355 ENSG00000026103
14  ENSG00000099985 NA OSM oncostatin M 5008 ENSG00000099985


Database:KEGG pathway       Name:Malaria       ID:05144
C=51; O=7; E=0.42; R=16.47; rawP=2.09e-07; adjP=2.79e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000108342 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
2  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
3  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
4  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
5  ENSG00000007908 NA SELE selectin E 6401 ENSG00000007908
6  ENSG00000090339 NA ICAM1 intercellular adhesion molecule 1 3383 ENSG00000090339
7  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:Rheumatoid arthritis       ID:05323
C=91; O=8; E=0.76; R=10.55; rawP=9.29e-07; adjP=9.29e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
2  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
3  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
4  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
5  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
6  ENSG00000090339 NA ICAM1 intercellular adhesion molecule 1 3383 ENSG00000090339
7  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
8  ENSG00000124875 NA CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 6372 ENSG00000124875


Database:KEGG pathway       Name:NOD-like receptor signaling pathway       ID:04621
C=58; O=6; E=0.48; R=12.42; rawP=8.66e-06; adjP=6.67e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
2  ENSG00000081041 NA CXCL2 chemokine (C-X-C motif) ligand 2 2920 ENSG00000081041
3  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
4  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
5  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
6  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:African trypanosomiasis       ID:05143
C=35; O=5; E=0.29; R=17.15; rawP=1.00e-05; adjP=6.67e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
2  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
3  ENSG00000007908 NA SELE selectin E 6401 ENSG00000007908
4  ENSG00000090339 NA ICAM1 intercellular adhesion molecule 1 3383 ENSG00000090339
5  ENSG00000026103 NA FAS Fas (TNF receptor superfamily, member 6) 355 ENSG00000026103


Database:KEGG pathway       Name:Chagas disease (American trypanosomiasis)       ID:05142
C=104; O=7; E=0.87; R=8.08; rawP=2.65e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000127666 NA TICAM1 toll-like receptor adaptor molecule 1 148022 ENSG00000127666
2  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
3  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
4  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
5  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
6  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
7  ENSG00000026103 NA FAS Fas (TNF receptor superfamily, member 6) 355 ENSG00000026103


Database:KEGG pathway       Name:Osteoclast differentiation       ID:04380
C=128; O=6; E=1.07; R=5.63; rawP=0.0007; adjP=0.0035
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
2  ENSG00000175592 NA FOSL1 FOS-like antigen 1 8061 ENSG00000175592
3  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
4  ENSG00000171223 NA JUNB jun B proto-oncogene 3726 ENSG00000171223
5  ENSG00000125740 NA FOSB FBJ murine osteosarcoma viral oncogene homolog B 2354 ENSG00000125740
6  ENSG00000184557 NA SOCS3 suppressor of cytokine signaling 3 9021 ENSG00000184557


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=7; E=1.57; R=4.45; rawP=0.0011; adjP=0.0049
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
2  ENSG00000081041 NA CXCL2 chemokine (C-X-C motif) ligand 2 2920 ENSG00000081041
3  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
4  ENSG00000108700 NA CCL8 chemokine (C-C motif) ligand 8 6355 ENSG00000108700
5  ENSG00000163734 NA CXCL3 chemokine (C-X-C motif) ligand 3 2921 ENSG00000163734
6  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
7  ENSG00000124875 NA CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 6372 ENSG00000124875


Database:KEGG pathway       Name:Toll-like receptor signaling pathway       ID:04620
C=102; O=5; E=0.85; R=5.88; rawP=0.0016; adjP=0.0064
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000127666 NA TICAM1 toll-like receptor adaptor molecule 1 148022 ENSG00000127666
2  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
3  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
4  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
5  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).